BOTOX® for Migrane
Following this discovery, Glogau and other researchers began to evaluate points and dosages that could alleviate migraine headaches. Glogau's results indicate that botulinum toxin A injected into the muscles of the brow, eyes, forehead, side of the head and back of the head near the neck (a point that earlier investigators have neglected) induce sometimes immediate headache relief and provide benefit for up to six months. Botox dosage in his case studies averaged 80 units per patient.
Dr. Glogau's case studies had long-standing diagnoses of migraines, had all seen neurologists, and were taking standard migraine medications, including sumatriptan (Imitrex). Some required narcotic medication to relieve the pain of their frequent headaches. Most suffered migraines on a minimum of once a week and several suffered on a daily basis.
Addition to the report by Dr. Glogau, published in the September-1998 issue of Dermatologi Surgery: "Other than prevention of wrinkles, BOTOX® is availing positive results to treat uncontrolled eye twitching, crossed eyes, muscle spasms and, most recently, excessive underarm sweating".
"I think it was accepted pretty quickly," said Emory University neurologist Dr. David Hewitt. "There are a number of people around the country who are using it off-label to treat headache."
BOTOX® is proving worth in treating migraines and other severe headaches. But there are still some uncertainties like:
a) What is the optimal dose of BOTOX®?
b) Where BOTOX® should be injected to get the best results?
Research is still continuing and two large studies are under way at headache clinics around the country that may provide those answers.